Abstract
Purpose
To investigate the functional and oncologic outcomes of patients with locally advanced
or lymph node (LN) metastatic prostate cancer (PCa) treated by laparoscopic radical
prostatectomy (LRP) with extended lymph node dissection (ePLND).
Methods
From June 2004 to March 2014, a total of 232 cases (pT3-4N0-1M0) including 160 locally
advanced PCa and 72 LN metastatic PCa who received immediate androgen deprivation
therapy after LRP plus ePLND were enrolled onto our study. The patients were followed
up for 12 to 124 months. Surgical records, surgical margin status, complications,
urinary continence, and oncologic outcomes were presented.
Results
The mean operation time and bleeding were 230 minutes and 105 mL, respectively. The
rates of urinary continence were 91.4% and 94.8% at 6 and 12 months, respectively.
We observed 122 biochemical recurrent cases. The 5- and 8-year biochemical relapse-free
survival rates were 47.3% and 46.7%, respectively. The 5- and 8-year overall and cancer-specific
survivals were 81.2%, 80.1%, 90.6%, and 90.6%, respectively. The survival analysis
showed that biochemical recurrence-free survival rates were significantly lower for
patients with higher Gleason score (77.3% vs. 39.6% vs. 30.8%, P = .003 log rank), higher T stage (55.7% vs. 41.4% vs. 21.4%, P = .039 log rank), positive surgical margin (51.1% vs. 29.3%, P = .000 log rank), and higher CAPRA-S score (68.6% vs. 35.0% vs. 29.2%, P = .000 log rank). There were no significant differences in biochemical relapse-free
(40.9% vs. 49.3%, P = .286), overall (75.6% vs. 81.9%, P = .398), and cancer-specific (87.3% vs. 92.1%, P = .284) survival between LN-positive and -negative PCa.
Conclusion
LRP plus ePLND in combination with immediate androgen deprivation therapy is a feasible
approach to patients with pT3-4N0-1M0 PCa; favorable functional and oncologic outcomes
were presented postoperatively.
Keywords
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Article info
Publication history
Published online: November 17, 2015
Accepted:
November 11,
2015
Received in revised form:
October 22,
2015
Received:
August 25,
2015
Footnotes
The first 2 authors contributed equally to this article, and both should be considered first author.
Identification
Copyright
© 2015 Elsevier Inc. All rights reserved.
