Abstract
Background
The significance of focal positive margins (FPMs) after radical prostatectomy (RP)
is unclear. Our objective was to investigate the prognostic value of FPMs in patients
undergoing RP.
Materials and Methods
The data were analyzed retrospectively for 1733 patients with clinically localized
prostate cancer who had undergone RP at our institution from December 2003 to March
2014 without neoadjuvant or adjuvant therapy. Positive surgical margins were characterized
as FPMs (≤ 3 mm long) or non-FPMs (> 3 mm long). Multivariate analysis of the clinicopathologic
factors, including FPMs, was performed with respect to biochemical recurrence (BCR)-free
survival.
Results
Of the 1733 patients, 1260 (72.7%) had negative margins, 114 (6.6%) had a FPM, 218
(12.6%) had a nonfocal single positive margin (NFSPM), and 141 (8.1%) had nonfocal
multiple positive margins (NFMPMs). Of the patients with pathologic T2 prostate cancer,
1065 (84.3%) had negative margins, 62 (4.9%) had 1 FPM, 104 (8.2%) had 1 NFSPM, and
33 (2.6%) had NFMPMs. The 5-year BCR-free survival for patients with negative margins
and FPMs was 90% and 83.4%, respectively. On multivariate analysis, the presence of
a FPM was not a significant prognostic factor for BCR-free survival in all the patients
or in the patients with pathologic T2 disease (P = .458 and P = .512, respectively).
Conclusions
FPMs after RP do not significantly affect BCR-free survival in patients with prostate
cancer.
Keywords
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Article info
Publication history
Published online: December 29, 2015
Accepted:
December 16,
2015
Received in revised form:
December 16,
2015
Received:
August 31,
2015
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
