Abstract
The objective is to evaluate the prognostic benefit of the Glasgow Prognostic Score
(GPS), neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and Prognostic
Nutrition Index (PNI) in patients with localized renal cell carcinoma undergoing nephrectomy
with curative intent. Embase and MEDLINE databases were searched for all publications
before April 2015. Duplicates were excluded, and inclusion/exclusion criteria were
applied to all abstracts; of those remaining, full articles were obtained and inclusion/exclusion
criteria were again applied, and the remaining articles were included and critically
appraised. Eight articles were included in this review. Three articles were included
for GPS. Outcomes included recurrence-free survival, cancer-specific survival (CSS),
and overall survival (OS). All articles demonstrated better prognosis associated with
a lower GPS on multivariate analysis: 1-year recurrence-free survival hazard ratio
(HR), 7.0 (P = .001); CSS HR, 6.7 to 8.6 (P < .001); and OS HR 4.2 (P < .001). Four articles were included for NLR. All articles demonstrated elevated
NLR to be associated with a poorer prognosis. Two articles demonstrated elevated NLR
to be associated with a lower progression-free survival. One article demonstrated
elevated NLR to be associated with a lower CSS (HR, 1.02, P = .009), and 2 articles demonstrated elevated NLR to be associated with a lower OS
(HR, 1.02-1.6). No articles were included for PLR, and only 1 article was identified
for PNI. There may be a role for modified GPS and NLR in patients with renal cell
carcinoma undergoing nephrectomy with curative intent. Evidence for PLR and PNI is
minimal.
Keywords
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Article info
Publication history
Published online: January 21, 2016
Accepted:
January 16,
2016
Received in revised form:
December 20,
2015
Received:
September 28,
2015
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
