Case Report| Volume 14, ISSUE 4, e409-e412, August 2016

Rare Case of Excessive Beta-Human Chorionic Gonadotropin Producing Intrascrotal Leiomyosarcoma: Diagnostic Pitfalls and Therapeutic Implications

Published:January 21, 2016DOI:
      It is known that LMS is capable of hormone production, such as b-hCG. These cases are extremely rare, and our report is one of the few with excessively elevated b-hCG levels in the blood serum.


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        • Coleman J.
        • Brennan M.F.
        • Alektiar K.
        • Russo P.
        Adult spermatic cord sarcomas: management and results.
        Ann Surg Oncol. 2003; 10: 669-675
        • Froehner M.
        • Gaertner H.J.
        • Manseck A.
        • Oehlschlaeger S.
        • Wirth M.P.
        Retroperitoneal leiomyosarcoma associated with an elevated beta-HCG serum level mimicking extragonadal germ cell tumor.
        Sarcoma. 2000; 4: 179-181
        • Rodriguez D.
        • Barrisford G.W.
        • Sanchez A.
        • Preston M.A.
        • Kreydin E.I.
        • Olumi A.F.
        Primary spermatic cord tumors: disease characteristics, prognostic factors, and treatment outcomes.
        Urol Oncol. 2014; 32: e19-e25
        • Galosi A.B.
        • Scarpelli M.
        • Mazzucchelli R.
        • et al.
        Adult primary paratesticular mesenchymal tumors with emphasis on a case presentation and discussion of spermatic cord leiomyosarcoma.
        Diagn Pathol. 2014; 9: 90
        • Beech D.J.
        • Pollock R.E.
        Surgical management of primary soft tissue sarcoma.
        Hematol Oncol Clin North Am. 1995; 9: 707-718
        • Catton C.
        • Jewett M.
        • O'Sullivan B.
        • Kandel R.
        Paratesticular sarcoma: failure patterns after definitive local therapy.
        J Urol. 1999; 161: 1844-1847
        • Mansi I.A.
        • Ashley I.
        • Glezerov V.
        Retroperitoneal leiomyosarcoma and enlarged epididymis associated with a positive pregnancy test.
        Am J Med Sci. 2002; 324: 104-105
        • Liang S.
        • Stone G.
        • Chalas E.
        • Pearl M.
        • Callan F.
        • Zheng W.
        A high-grade uterine leiomyosarcoma with human chorionic gonadotropin production.
        Int J Gynecol Pathol. 2006; 25: 257-261
        • Kelley B.C.
        • Arnold P.M.
        • Grant J.A.
        • Newell K.L.
        Primary intracranial beta-human chorionic gonadotropin-producing leiomyosarcoma in a 2-year-old immunocompetent child.
        J Neurosurg Pediatr. 2012; 10: 121-125
        • Ou S.M.
        • Lee S.S.
        • Peng Y.J.
        • Sheu L.F.
        • Yao N.S.
        • Chang S.Y.
        Production of beta-HCG by spermatic cord leiomyosarcoma: a paraneoplastic syndrome?.
        J Androl. 2006; 27: 643-644