Case Report| Volume 14, ISSUE 4, e441-e443, August 2016

High-Dose Chemotherapy in a Late Relapse, Platinum-Refractory Nonseminomatous Germ Cell Tumor

Published:March 12, 2016DOI:
      Nonseminomatous germ cell tumors (NSGCT) are curable, even with unresectable metastatic disease.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Clinical Genitourinary Cancer
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • International Germ Cell Cancer Collaborative Group
        International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers.
        J Clin Oncol. 1997; 15: 594-603
        • Oldenburg J.
        • Martin J.M.
        • Fossa S.D.
        Late relapses of germ cell malignancies: incidence, management, and prognosis.
        J Clin Oncol. 2006; 24: 5503-5511
        • Sharp D.S.
        • Carver B.S.
        • Eggener S.E.
        • et al.
        Clinical outcome and predictors of survival in late relapse of germ cell tumor.
        J Clin Oncol. 2008; 26: 5524-5529
        • George D.W.
        • Foster R.S.
        • Hromas R.A.
        • et al.
        Update on late relapse of germ cell tumor: a clinical and molecular analysis.
        J Clin Oncol. 2003; 21: 113-122
        • Ronnen E.A.
        • Kondagunta G.V.
        • Bacik J.
        • et al.
        Incidence of late-relapse germ cell tumor and outcome to salvage chemotherapy.
        J Clin Oncol. 2005; 23: 6999-7004
        • Einhorn L.H.
        • Williams S.D.
        • Chamness A.
        • Brames M.J.
        • Perkins S.M.
        • Abonour R.
        High-dose chemotherapy and stem-cell rescue for metastatic germ-cell tumors.
        N Engl J Med. 2007; 357: 340-348
        • Lorch A.
        • Kleinhans A.
        • Kramar A.
        • et al.
        Sequential versus single high-dose chemotherapy in patients with relapsed or refractory germ cell tumors: long-term results of a prospective randomized trial.
        J Clin Oncol. 2012; 30: 800-805
        • Lorch A.
        • Rick O.
        • Wündisch T.
        • Hartmann J.T.
        • Bokemeyer C.
        • Beyer J.
        High dose chemotherapy as salvage treatment for unresectable late relapse germ cell tumors.
        J Urol. 2010; 184: 168-173