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Case Report| Volume 14, ISSUE 4, e449-e452, August 2016

Targeted Therapy Based on Tumor Genomic Analyses in Metastatic Urachal Carcinoma

Published:March 24, 2016DOI:https://doi.org/10.1016/j.clgc.2016.03.013
      Urachal cancer is rare and has a prevalence of approximately 0.2%.

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      References

        • Molina J.R.
        • Quevedo J.F.
        • Furth A.F.
        • Richardson R.L.
        • Zincke H.
        • Burch P.A.
        Predictors of survival from urachal cancer: a Mayo Clinic study of 49 cases.
        Cancer. 2007; 110: 2434-2440
        • Bruins H.M.
        • Visser O.
        • Ploeg M.
        • Hulsbergen-van de Kaa C.A.
        • Kiemeney L.A.
        • Witjes J.A.
        The clinical epidemiology of urachal carcinoma: results of a large, population-based study.
        J Urol. 2012; 188: 1102-1107
        • Elser C.
        • Sweet J.
        • Cheran S.K.
        • Haider M.A.
        • Jewett M.
        • Sridhar S.S.
        A case of metastatic urachal adenocarcinoma treated with several different chemotherapeutic regimens.
        Can Urol Assoc J. 2012; 6: E27-E31
        • Siefker-Radtke A.O.
        • Gee J.
        • Shen Y.U.
        • et al.
        Multimodality management of urachal carcinoma: the M. D. Anderson Cancer Center Experience.
        J Urol. 2003; 169: 1295-1298
      1. National Cancer Institute. Common Terminology Criteria for Adverse Events v4.0. NIH publication #09–7473. NCI, NIH, DHHS. 2009 May 29. Available at: http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf.

        • Logothetis C.J.
        • Samuels M.L.
        • Ogden S.
        Chemotherapy for adenocarcinomas of bladder and urachal origin: 5-fluorouracil, doxorubicin, and mitomycin-C.
        Urology. 1985; 26: 252-255
        • Mohile S.G.
        • Schleicher L.
        • Petrylak D.P.
        Treatment of metastatic urachal carcinoma in an elderly woman.
        Nat Clin Pract Oncol. 2008; 5: 55-58
        • Piégay F.
        • Mornex J.-F.
        Combined modalities treatment of pulmonary metastasis from an urachal adenocarcinoma.
        Rare Tumors. 2013; 5: e32
        • Kawakami S.
        • Kageyama Y.
        • Yonese J.
        • et al.
        Successful treatment of metastatic adenocarcinoma of the urachus: report of 2 cases with more than 10-year survival.
        Urology. 2001; 58: 462
        • Tatokoro M.
        • Kawakami S.
        • Yonese J.
        • et al.
        Preliminary report of multimodal treatment with ifosfamide, 5-fluorouracil, etoposide, and cisplatin (IFEP chemotherapy) against metastatic adenocarcinoma of the urachus.
        Int J Urol. 2008; 15: 851-853
        • Hongoh S.
        • Nomoto T.
        • Kawakami M.
        • Hanai K.
        • Inatsuchi H.
        • Terachi T.
        Complete response to M-FAP chemotherapy for multiple lung metastases after segmental resection of urachal carcinoma: a case report.
        Hinyokika Kiyo. 2010; 56: 107-110
        • Galsky M.D.
        • Iasonos A.
        • Mironov S.
        • et al.
        Prospective trial of ifosfamide, paclitaxel, and cisplatin in patients with advanced non-transitional cell carcinoma of the urothelial tract.
        Urology. 2007; 69: 255-259
        • Sekita N.
        • Fujimura M.
        • Arai H.
        • et al.
        A case of urachal carcinoma treated with S-1/CDDP combination chemotherapy.
        Hinyokika Kiyo. 2010; 56: 447-451
        • Kojima Y.
        • Yamada Y.
        • Kamisawa H.
        • Sasaki S.
        • Hayashi Y.
        • Kohri K.
        Complete response of a recurrent advanced urachal carcinoma treated by S-1/cisplatin combination chemotherapy.
        Int J Urol. 2006; 13: 1123-1125
        • Kume H.
        • Tomita K.
        • Takahashi S.
        • Fukutani K.
        Irinotecan as a new agent for urachal cancer.
        Urol Int. 2006; 76: 281-282
        • Testa I.
        • Verzoni E.
        • Grassi P.
        • Colecchia M.
        • Panzone F.
        • Procopio G.
        Response to targeted therapy in urachal adenocarcinoma.
        Rare Tumors. 2014; 6: 5529
        • Sirintrapun S.J.
        • Ward M.
        • Woo J.
        • Cimic A.
        High-stage urachal adenocarcinoma can be associated with microsatellite instability and KRAS mutations.
        Hum Pathol. 2014; 45: 327-330
        • Vaughn C.P.
        • Zobell S.D.
        • Furtado L.V.
        • Baker C.L.
        • Samowitz W.S.
        Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancer.
        Genes Chromosomes Cancer. 2011; 50: 307-312
        • Boland C.R.
        • Goel A.
        Microsatellite instability in colorectal cancer.
        Gastroenterology. 2010; 138: 2073-2087.e3
        • Langer C.J.
        Roles of EGFR and KRAS mutations in the treatment of patients with non–small-cell lung cancer.
        Pharm Ther. 2011; 36: 263-279
        • Pao W.
        • Wang T.Y.
        • Riely G.J.
        • et al.
        KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib.
        PLoS Med. 2005; 2: e17
        • Wilson C.
        • McIntyre R.
        • Arends M.
        • Adams D.
        The activating mutation R201C in GNAS promotes intestinal tumourigenesis in ApcMin/+ mice via activation of Wnt and ERK1/2 MAPK pathways.
        Oncogene. 2010; 29: 4567-4575
        • Jänne P.A.
        • Shaw A.T.
        • Pereira J.R.
        • et al.
        Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study.
        Lancet Oncol. 2013; 14: 38-47
        • Eisenhauer E.A.
        • Therasse P.
        • Bogaerts J.
        • et al.
        New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).
        Eur J Cancer. 2009; 45: 228-247
        • Rocnik J.L.
        • Okabe R.
        • Yu J.-C.
        • et al.
        Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.
        Blood. 2006; 108: 1339-1345
        • Choudhary C.
        • Schwäble J.
        • Brandts C.
        • et al.
        AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.
        Blood. 2005; 106: 265-273
        • Schnittger S.
        • Schoch C.
        • Dugas M.
        • et al.
        Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease.
        Blood. 2002; 100: 59-66
        • Fröhling S.
        • Schlenk R.F.
        • Breitruck J.
        • et al.
        Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.
        Blood. 2002; 100: 4372-4380
        • Fiedler W.
        • Kayser S.
        • Kebenko M.
        • et al.
        A phase I/II study of sunitinib and intensive chemotherapy in patients over 60 years of age with acute myeloid leukaemia and activating FLT3 mutations.
        Br J Haematol. 2015; 169: 694-700
        • Man C.H.
        • Fung T.K.
        • Ho C.
        • et al.
        Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.
        Blood. 2012; 119: 5133-5143
        • Marks J.L.
        • Gong Y.
        • Chitale D.
        • et al.
        Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma.
        Cancer Res. 2008; 68: 5524-5528
        • Nelson D.S.
        • van Halteren A.
        • Quispel W.T.
        • et al.
        MAP2K1 and MAP3K1 mutations in Langerhans cell histiocytosis.
        Genes Chromosomes Cancer. 2015; 54: 361-368
        • Catalanotti F.
        • Solit D.B.
        • Pulitzer M.P.
        • et al.
        Phase II trial of MEK inhibitor selumetinib (AZD6244, ARRY-142886) in patients with BRAFV600E/K- mutated melanoma.
        Clin Cancer Res. 2013; 19: 2257-2264
        • Arcila M.E.
        • Drilon A.
        • Sylvester B.E.
        • et al.
        MAP2K1 (MEK1) mutations define a distinct subset of lung adenocarcinoma associated with smoking.
        Clin Cancer Res. 2015; 21: 1935-1943
        • Nikolaev S.I.
        • Rimoldi D.
        • Iseli C.
        • et al.
        Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.
        Nat Genet. 2012; 44: 133-139
        • Slattery M.L.
        • Lundgreen A.
        • Wolff R.K.
        MAP kinase genes and colon and rectal cancer.
        Carcinogenesis. 2012; 33: 2398-2408
        • Flaherty K.T.
        • Robert C.
        • Hersey P.
        • et al.
        Improved survival with MEK inhibition in BRAF-mutated melanoma.
        N Engl J Med. 2012; 367: 107-114
        • Robert C.
        • Karaszewska B.
        • Schachter J.
        • et al.
        Improved overall survival in melanoma with combined dabrafenib and trametinib.
        N Engl J Med. 2015; 372: 30-39
        • Dócs O.
        • Fazakas F.
        • Horváth N.L.
        • et al.
        Changes of KRAS exon 2 codon 12/13 mutation status in recurrent colorectal cancer.
        Pathol Oncol Res. 2015; 21: 399-404
        • Bai H.
        • Wang Z.
        • Chen K.
        • et al.
        Influence of chemotherapy on EGFR mutation status among patients with non-small-cell lung cancer.
        J Clin Oncol. 2012; 30: 3077-3083
        • Antonarakis E.S.
        • Lu C.
        • Luber B.
        • et al.
        Androgen receptor splice variant 7 and efficacy of taxane chemotherapy in patients with metastatic castration-resistant prostate cancer.
        JAMA Oncol. 2015; 1: 582-591
        • Zahreddine H.
        • Borden K.L.B.
        Mechanisms and insights into drug resistance in cancer.
        Front Pharmacol. 2013; 4: 28
        • Gerlinger M.
        • Rowan A.J.
        • Horswell S.
        • et al.
        Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
        N Engl J Med. 2012; 366: 883-892