Case Report| Volume 14, ISSUE 4, e453-e456, August 2016

Pharmacokinetic Analysis of a Hemodialyzed Patient Treated With Pazopanib

Published:March 24, 2016DOI:
      Pazopanib, an oral multitargeted tyrosine inhibitor, is approved for the treatment of advanced and/or metastatic renal cell carcinoma (RCC) as the first-line treatment. However, no information is available regarding the dosage adjustment of pazopanib for patients undergoing hemodialysis. Therefore, evaluation of the influence of dialysis treatment on pazopanib pharmacokinetics is needed.


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        • Cohen H.T.
        • McGovern F.J.
        Renal-cell carcinoma.
        N Engl J Med. 2005; 353: 2477-2490
        • Motzer R.J.
        • Hutson T.E.
        • Cella D.
        • et al.
        Pazopanib versus sunitinib in metastatic renal-cell carcinoma.
        N Engl J Med. 2013; 369: 722-731
        • Escudier B.
        • Porta C.
        • Bono P.
        • et al.
        Randomized, controlled, double-blind, cross-over trial assessing treatment preference for pazopanib versus sunitinib in patients with metastatic renal cell carcinoma: PISCES Study.
        J Clin Oncol. 2014; 32: 1412-1418
        • Kitai Y.
        • Matsubara T.
        • Yanagita M.
        Onco-nephrology: current concepts and future perspectives.
        Jpn J Clin Oncol. 2015; 45: 617-628
        • Heath E.I.
        • Chiorean E.G.
        • Sweeney C.J.
        • et al.
        A phase I study of the pharmacokinetic and safety profiles of oral pazopanib with a high-fat or low-fat meal in patients with advanced solid tumors.
        Clin Pharmacol Ther. 2010; 88: 818-823
        • Kumar R.
        • Knick V.B.
        • Rudolph S.K.
        • et al.
        Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity.
        Mol Cancer Ther. 2007; 6: 2012-2021
        • Suttle A.B.
        • Ball H.A.
        • Molimard M.
        • et al.
        Relationships between pazopanib exposure and clinical safety and efficacy in patients with advanced renal cell carcinoma.
        Br J Cancer. 2014; 111: 1909-1916
        • Pick A.M.
        • Nystrom K.K.
        Pazopanib for the treatment of metastatic renal cell carcinoma.
        Clin Ther. 2012; 34: 511-520
        • Shetty A.V.
        • Matrana M.R.
        • Atkinson B.J.
        • et al.
        Outcomes of patients with metastatic renal cell carcinoma and end-stage renal disease receiving dialysis and targeted therapies: a single institution experience.
        Clin Genitourin Cancer. 2014; 12: 348-353
        • Czarnecka A.M.
        • Kawecki M.
        • Lian F.
        • et al.
        Feasibility, efficacy and safety of tyrosine kinase inhibitor treatment in hemodialyzed patients with renal cell cancer: 10 years of experience.
        Future Oncol. 2015; 11: 2267-2282
        • Terada T.
        • Noda S.
        • Inui K.
        Management of dose variability and side effects for individualized cancer pharmacotherapy with tyrosine kinase inhibitors.
        Pharmacol Ther. 2015; 152: 125-134
        • Izzedine H.
        • Etienne-Grimaldi M.C.
        • Renée N.
        • et al.
        Pharmacokinetics of sunitinib in hemodialysis.
        Ann Oncol. 2009; 20: 190-192
        • Noda S.
        • Kageyama S.
        • Tsuru T.
        • et al.
        Pharmacokinetic/pharmacodynamic analysis of a hemodialyzed patient treated with 25 mg of sunitinib.
        Case Rep Oncol. 2012; 5: 627-632
        • Shinsako K.
        • Mizuno T.
        • Terada T.
        • et al.
        Tolerable sorafenib therapy for a renal cell carcinoma patient with hemodialysis: a case study.
        Int J Clin Oncol. 2010; 15: 512-514
        • Togashi Y.
        • Masago K.
        • Fukudo M.
        • et al.
        Pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small cell lung cancer and chronic renal failure who are undergoing hemodialysis.
        J Thorac Oncol. 2010; 5: 601-605
        • Janus N.
        • Thariat J.
        • Boulanger H.
        • et al.
        Proposal for dosage adjustment and timing of chemotherapy in hemodialyzed patients.
        Ann Oncol. 2010; 21: 1395-1403
        • Hurwitz H.I.
        • Dowlati A.
        • Saini S.
        • et al.
        Phase I trial of pazopanib in patients with advanced cancer.
        Clin Cancer Res. 2009; 15: 4220-4227