Abstract
Background
We aimed to investigate the outcomes of interferon alfa and sequencing tyrosine kinase
inhibitors (TKIs) in patients with metastatic renal cell carcinoma.
Patients and Methods
This multicenter study assessing the efficacy of TKIs after interferon alfa therapy
in the first-line setting in patients with metastatic renal cell carcinoma. Patients (n =
104) from 8 centers in Turkey, who had been treated with interferon alfa in the first-line
setting, were included in the study. Prognostic factors were evaluated for progression-free
survival (PFS).
Results
The median age of the patients was 57 years. The median PFS of the patients treated
with interferon alfa in the first-line was 3.6 months. A total of 61 patients received
TKIs (sunitinib, n = 58; sorafenib, n = 3) after progression while on interferon alfa.
The median PFS among the TKI-treated patients was 13.2 months. In the univariate analysis
for interferon alfa treatment, neutrophil and hemoglobin level, platelet count, and
Karnofsky performance status were the significant factors associated with PFS. In
the univariate analysis for TKI treatment, neutrophil and hemoglobin levels were the
significant factors for PFS. The median total PFS of the patients who had been treated
with first-line interferon alfa and second-line TKIs was 24.9 months.
Conclusion
This study showed that first-line interferon alfa treatment before TKIs may improve
the total PFS in patients with metastatic renal cell carcinoma.
Keywords
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Article info
Publication history
Published online: May 02, 2016
Accepted:
April 25,
2016
Received in revised form:
April 20,
2016
Received:
October 14,
2015
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
