Abstract
Background
Men diagnosed with prostate cancer have increased risk for disease progression, cardiovascular
events, and impairments in quality of life. This pilot study evaluated the feasibility
of a randomized walking group intervention to improve quality of life, circulating
biomarkers, and morbidity among men with newly diagnosed prostate cancer.
Methods
Men were recruited at Örebro University Hospital, Sweden, and randomized to an 11-week
walking group intervention (n = 21) or usual care (n = 20). The intervention included
weekly 1-hour walking group sessions and maintenance of 10,000 steps/day. Outcomes
were changes in body composition, clinical factors, biomarkers of cardiovascular health,
and quality of life between baseline and end of study. Analysis of covariance was
used to compare outcomes in each group adjusted for baseline values.
Results
All 41 men randomized completed the 11-week trial. Men assigned to the intervention
walked on average 10,644 steps/day, and 92% reported missing 2 or fewer sessions.
Both groups experienced similar weight loss at 11 weeks. Men in the intervention had
a significant adjusted mean change in high-density lipoprotein of 0.14 mmol/L (95%
confidence interval [CI], 0.01-0.27; P = .04), and suggestive adjusted mean changes in low-density lipoprotein of −0.22 mmol/L
(95% CI, −0.47 to 0.03; P = .08) and in systolic blood pressure of −8.5 mm Hg (95% CI, −21.2 to 4.2; P = .18), compared with the usual care group.
Conclusions
A walking group intervention among men with recent diagnosis of prostate cancer is
feasible and potentially effective in improving cardiovascular health. A larger randomized
trial of longer duration is required to elucidate its potential for improvement in
longer term outcomes.
Keywords
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References
- Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.Lancet. 2015; 386: 743-800
- Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.Int J Cancer. 2015; 136: E359-E386
- Long-term outcomes among noncuratively treated men according to prostate cancer risk category in a nationwide, population-based study.Eur Urol. 2013; 63: 88-96
- Temporal trends in cause of death among Swedish and US men with prostate cancer.J Natl Cancer Inst. 2012; 104: 1335-1342
- Quality of life and satisfaction with outcome among prostate-cancer survivors.N Engl J Med. 2008; 358: 1250-1261
- Quality of life after radical prostatectomy or watchful waiting.N Engl J Med. 2002; 347: 790-796
- Current prostate cancer treatments: effect on quality of life.Urology. 2009; 73: S28-S35
- Immediate risk for cardiovascular events and suicide following a prostate cancer diagnosis: prospective cohort study.PLoS Med. 2009; 6: e1000197
- Immediate risk of suicide and cardiovascular death after a prostate cancer diagnosis: cohort study in the United States.J Natl Cancer Inst. 2010; 102: 307-314
- Lifestyle intervention in men with advanced prostate cancer receiving androgen suppression therapy: a feasibility study.Cancer Epidemiol Biomarkers Prev. 2011; 20: 647-657
- Physical activity and survival after breast cancer diagnosis.JAMA. 2005; 293: 2479-2486
- Physical activity and survival after prostate cancer diagnosis in the health professionals follow-up study.J Clin Oncol. 2011; 29: 726-732
- Physical activity and survival after colorectal cancer diagnosis.J Clin Oncol. 2006; 24: 3527-3534
- Physical activity after diagnosis and risk of prostate cancer progression: data from the cancer of the prostate strategic urologic research endeavor.Cancer Res. 2011; 71: 3889-3895
- Physical activity and survival among men diagnosed with prostate cancer.Cancer Epidemiol Biomarkers Prev. 2015; 24: 57-64
- Does physiotherapist-guided pelvic floor muscle training reduce urinary incontinence after radical prostatectomy? A randomised controlled trial.Eur Urol. 2008; 54: 438-448
- Preoperative pelvic floor muscle exercise for early continence after radical prostatectomy: a randomised controlled study.Eur Urol. 2010; 57: 1039-1043
- Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial.J Clin Oncol. 2010; 28: 340-347
- Physical activity for men receiving androgen deprivation therapy for prostate cancer: benefits from a 16-week intervention.Support Care Cancer. 2010; 18: 591-599
- Effects of a 1-week inpatient course including information, physical activity, and group sessions for prostate cancer patients.J Cancer Educ. 2011; 26: 754-760
- Recovery of overall exercise ability, quality of life, and continence after 12-week combined exercise intervention in elderly patients who underwent radical prostatectomy: a randomized controlled study.Urology. 2012; 80: 299-305
- Exercise effects on depressive symptoms in cancer survivors: a systematic review and meta-analysis.Cancer Epidemiol Biomarkers Prev. 2012; 21: 3-19
- Riding the crest of the teachable moment: promoting long-term health after the diagnosis of cancer.J Clin Oncol. 2005; 23: 5814-5830
- A global measure of perceived stress.J Health Soc Behav. 1983; 24: 385-396
- The hospital anxiety and depression scale.Acta Psychiatr Scand. 1983; 67: 361-370
- Psychometric evaluation and normative data for the Karolinska Sleep Questionnaire.Sleep Biol Rhythms. 2013; 11: 216-226
- Cohort Profile: the National Prostate Cancer Register of Sweden and Prostate Cancer data Base Sweden 2.0.Int J Epidemiol. 2013; 42: 956-967
- How many steps are enough? Dose-response curves for pedometer steps and multiple health markers in a community-based sample of older Australians.J Phys Act Health. 2014; 11: 509-518
- How many steps/day are enough? Preliminary pedometer indices for public health.Sports Med. 2004; 34: 1-8
- Comparing eccentric resistance exercise in prostate cancer survivors on and off hormone therapy: a pilot study.PM R. 2009; 1: 1019-1024
- Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer.J Clin Oncol. 2009; 27: 344-351
- A multicentre year-long randomised controlled trial of exercise training targeting physical functioning in men with prostate cancer previously treated with androgen suppression and radiation from TROG 03.04 RADAR.Eur Urol. 2014; 65: 856-864
- Effects of nonlinear aerobic training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically localized prostate cancer.Eur Urol. 2014; 65: 852-855
- Long-term effects of androgen deprivation therapy in prostate cancer patients.Clin Endocrinol (Oxf). 2002; 56: 779-786
- Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy.Arch Phys Med Rehabil. 2007; 88: 1416-1422
- Moderator analyses of participants in the Active for Life after cancer trial: implications for physical activity group intervention studies.Ann Behav Med. 2007; 33: 99-104
- A randomized, controlled trial of aerobic exercise for treatment-related fatigue in men receiving radical external beam radiotherapy for localized prostate carcinoma.Cancer. 2004; 101: 550-557
- Adverse effects of androgen deprivation therapy and strategies to mitigate them.Eur Urol. 2015; 67: 825-836
Article info
Publication history
Published online: May 30, 2017
Accepted:
May 23,
2017
Received in revised form:
May 18,
2017
Received:
March 1,
2017
Footnotes
U.V., O.A., and L.A.M. contributed equally to this work.
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
