Abstract
Background
Everolimus (E) and axitinib (A) have been standard treatments for patients with metastatic
renal cell carcinoma after failure of first-line therapy (1L) with vascular endothelial
growth factor-targeted therapy. This study aims to compare both drugs in a large comprehensive
cancer center.
Methods
Patient characteristics and outcome data from all patients with metastatic renal cell
carcinoma who received E or A as second-line therapy at Gustave Roussy from April
2007 to May 2015 have been recorded.
Results
A total of 81 patients were treated with E and 45 patients with A. There were no major
differences between the 2 groups. The most common 1L was sunitinib (79% in the E group
and 82.2% in the A group). The median follow-up was 29 months; 26 months for A and
33 months for E (P = .046). The median overall survival (OS) was 21.5 months for E and 14.9 months for
A (P = .23). The median progression-free survival (PFS) was 5.3 and 7.7 months for E and
A, respectively (P = .39). Partial response was achieved in 4% and in 24% of patients (P = .002) in the E and A cohort, respectively. In the A group, the median PFS and OS
were statistically different according to response, tumor burden, and 1L duration.
No differences were found in the E arm.
Conclusion
In this series, there are no significant differences for PFS and OS with E and A.
A appears to provide more objective response. A appears to be more effective in patients
with small tumor burden, responders to 1L, and 1L therapy > 12 months.
Keywords
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Article info
Publication history
Published online: August 11, 2017
Accepted:
July 21,
2017
Received in revised form:
July 18,
2017
Received:
December 9,
2016
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
