Abstract
Background
The 5-year overall survival (OS) of patients with metastatic renal cell carcinoma
(mRCC) has been rarely reported. The aim of the RENSUR5 registry study was to obtain
real-world data on the use of therapy for mRCC and assess the 5-year OS in the Russian
population.
Patient and Methods
Patients were retrospectively identified at 11 cancer centers in different regions
of Russia (Astrakhan, Barnaul, Ekaterinburg, Kazan, Krasnoyarsk, Obninsk, Omsk, Rostov-on-Don,
Samara, St. Petersburg, and Ufa). Patients were included if mRCC had been diagnosed
from January 2010 to January 2011. Anonymized data were collected through an online
registry covering the demographic data, treatments, and outcomes.
Results
A total of 439 adult mRCC patients were included in the present study for analysis.
The mean age at diagnosis of mRCC was 60.9 years (range, 33-90 years; with 9% of patients
aged ≥ 75 years). The patients were predominantly men (70.2%) and 67.7% had nephrectomy.
Clear cell and non–clear cell tumors were detected in 61.1% and 7.7% of patients,
respectively. A total of 271 patients (62%) received systemic therapy. The median
duration of therapy was 11 months (95% confidence interval, 9.5-12.5 months). Most
treatment was with interferon only (n = 145); 105 patients (23.9%) received targeted
therapy, and 69 patients (15.7%) received ≥ 2 treatment lines. The 1-, 3-, and 5-year
OS rate was 49.4%, 18.9%, and 8.2%, respectively. The median OS from the start of
treatment was 12 months (95% confidence interval, 9.7-14.4 months).
Conclusion
RENSUR5 is a large real-world database assessing the mRCC treatment patterns and 5-year
OS in Russia. According to the first results of the present study, we believe that
5-year OS should improve with novel therapies. The limited administration of targeted
therapies was reflected by the results of the 5-year survival rate. The treatment
of mRCC has changed in the past years with new treatment options significantly improving
OS. The 5-year OS of patients treated with immunotherapy and targeted therapy should
be analyzed in the real world.
Keywords
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Article info
Publication history
Published online: August 08, 2017
Accepted:
July 21,
2017
Received in revised form:
July 18,
2017
Received:
April 27,
2017
Identification
Copyright
© 2017 Elsevier Inc. All rights reserved.
