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Renal Cell Carcinoma Pseudoprogression with Clinical Deterioration: To Hospice and Back

  • Roy Elias
    Affiliations
    Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX

    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX
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  • Payal Kapur
    Affiliations
    Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX

    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX
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  • Ivan Pedrosa
    Affiliations
    Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX

    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX
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  • James Brugarolas
    Correspondence
    Address for correspondence: James Brugarolas, MD, PhD, Department of Internal Medicine & Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390
    Affiliations
    Kidney Cancer Program, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX

    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX
    Search for articles by this author
      Increasing adoption of immune checkpoint inhibitors in the management of renal cell carcinoma is resulting in a higher rate of atypical responses. They include pseudoprogression, where initial tumor growth is followed by response, and hyperprogression, where there is accelerated growth rate after discontinuation of the previous therapy.

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