Abstract
The addition of docetaxel and abiraterone to androgen deprivation therapy (ADT) heralded
a new era in the first-line treatment of metastatic castration-sensitive prostate
cancer (mCSPC). Following the success of these combination regimens, 3 new trials
presented data on using enzalutamide or apalutamide in men with mCSPC, which showed
similar success. These seminal trials collectively established the addition of docetaxel,
enzalutamide, apalutamide, or abiraterone to ADT as standards in the upfront treatment
of mCSPC. Notably, a subset of patients in these more recent trials were treated with
a combination of docetaxel, ADT, and androgen receptor signaling inhibitors or maintenance
androgen receptor signaling inhibitors after docetaxel and ADT that provided an initial
glimpse into the efficacy of these triplet or maintenance strategies. We discuss the
implications of these recent findings and place them in context of the current mCSPC
treatment landscape.
Keywords
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Article info
Publication history
Published online: May 10, 2020
Accepted:
May 3,
2020
Received in revised form:
May 1,
2020
Received:
February 19,
2020
Footnotes
J.J.A. and J.P.R. contributed equally to this work as first authors.
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
