Abstract
Background
Mutations in several common hereditary cancer genes are associated with prostate cancer,
but there is limited information on the prevalence of these mutations in Hispanic
men.
Materials and Methods
We selected men at high risk for genetic mutations from 1515 Hispanic men enrolled
in the San Antonio Biomarkers of Risk for prostate cancer (SABOR) cohort. Inclusion
criteria included men with a diagnosis of prostate cancer or a first-degree family
history of prostate cancer. We performed germline genetic testing using the Color
Genomics platform, sequencing 30 genes associated with hereditary cancer risk. Additionally,
we assessed ancestral informative markers to determine the admixture of the ethnically
unique cohort.
Results
Of the 275 subjects who met selection criteria, 263 patients had sufficient samples
for sequencing. We identified 3.8% of patients (10 of 263) with a pathogenic or likely
pathogenic mutation in the 30 genes tested, of whom 70% would not have met established
criteria for genetic testing. Six of these mutations were in BRCA1/2 or ATM. There was a significant inverse association between the percentage of Native American
ancestry and the risk of prostate cancer, OR 0.11 (95% CI 0.02-0.76, P = .025).
Conclusion
Hispanic men with either a personal or family history of prostate cancer carry mutations
in hereditary cancer genes at a significant rate, on par with non–Hispanic counterparts
with similar risk factors.
Keywords
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Article info
Publication history
Published online: January 14, 2022
Accepted:
January 9,
2022
Received in revised form:
December 5,
2021
Received:
May 11,
2021
Identification
Copyright
© 2022 Published by Elsevier Inc.
