Highlights
- •In small cell carcinoma of the bladder, neoadjuvant chemotherapy improves survival.
- •Pathologic response is associated with superior long-term survival.
- •Metastatic disease is associated with poor clinical outcomes.
- •Small cell carcinoma of the bladder harbors high tumor mutation burden.
- •ERCC2 mutations are associated with complete response to neoadjuvant chemotherapy.
Abstract
Introduction
Small cell carcinoma of the bladder (SCCB) is a rare variant of bladder cancer with
poor outcomes. We evaluated long-term outcomes of nonmetastatic (M0) and metastatic
(M1) SCCB and correlated pathologic response with genomic alterations of patients
treated with neoadjuvant chemotherapy (NAC).
Patients and Methods
Clinical history and pathology samples from SCCB patients diagnosed at our institution
were reviewed.
Results
One hundred and ninety-nine SCCB patients were identified. (M0: 147 [74%]; M1: 52
[26%]). Among M0 patients, 108 underwent radical cystectomy (RC) (NAC: 71; RC only:
23; adjuvant chemotherapy: 14); 14 received chemoradiotherapy; the rest received chemotherapy
alone or no cancer-directed therapy. RC-only patients had a median follow-up of 9.1
years, and median disease-free survival (DFS) and overall survival (OS) were 1.1 and
1.2 years, respectively. NAC patients had pathologic response (<pT2pN0) and pathologic
complete response (pT0pN0) rates of 48% and 38%, respectively, with median follow-up
of 7.2 years, and median DFS and OS of 5.6 and 14.5 years, respectively. NAC responders
(<ypT2N0) had superior median DFS (14.5 vs. 0.6 years, hazard ratio [HR] 0.24, P< .001) and OS (14.5 vs. 2.5 years, HR 0.31, P = .002). DFS rates for responders and nonresponders were 76% and 27% at 5 years,
and 71% and 23% at 10 years, respectively. Local and central nervous system recurrences
were infrequent. Median progression-free survival (PFS) and OS for M1 disease were
6.9 and 10.3 months, respectively. Genomic profiling was performed on 47 NAC patients.
Loss of ERCC2 function was significantly enriched among those with pathologic complete
response to NAC (mutations present in 50% of pathologic complete responders vs. 15%
nonresponders, P = .045).
Conclusion
M0 SCCB is chemo-sensitive and patients have excellent long-term survival following
response to NAC. Patients with M1 disease have poor survival despite systemic therapy.
Loss-of-function mutations of ERCC2 were associated with pathologic complete response
to NAC.
Keywords
Abbreviations:
CNS (Central nervous system), DFS (Disease-free survival), FGA (Fraction of genome altered), HR (Hazard ratio), M0 (Non-metastatic), M1 (Metastatic), MSK-IMPACT (Memorial Sloan Kettering Integrated Mutation Profiling of Actionable Cancer Targets), NAC (Neoadjuvant chemotherapy), NOS (Not otherwise specified), OS (Overall survival), PFS (Progression-free survival), RC (Radical cystectomy), SCCB (Small cell carcinoma of the bladder), TMB (Tumor mutation burden)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: May 10, 2022
Accepted:
May 8,
2022
Received in revised form:
May 5,
2022
Received:
January 17,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
