Abstract
Background
Upper tract urothelial carcinomas (UTUCs) arise in the renal pelvis or the ureter,
accounting for approximately 5% of all urothelial carcinomas. Recent years have witnessed
the publication of several studies aimed at assessing the molecular, biologic, and
clinical features of UTUC, reporting that FGFR3 mutations are the most observed genetic aberrations; however, several knowledge gaps
persist in the understanding of the genomic landscape of this genitourinary malignancy
with few treatment options.
Patients and Methods
In the current study, we aimed to comprehensively analyze clinicopathological features
of FGFR3-mutated UTUCs patients in public datasets to increase the current knowledge of the
molecular and biologic profile of UTUC. Data regarding clinical outcomes, mutational
profiles, and copy number alterations in patients affected by UTUC were downloaded
from the cBioPortal for Cancer Genomics Database. UTUC data were available from 4
studies, for a total number of 358 patients; among these, 150 UTUC patients presented
FGFR3 mutations.
Results
The current database analysis of the mutational profile of 150 FGFR3-mutated UTUCs suggested that FGFR3 mutations may represent a prognostic factor in this disease, with a statistically
longer overall survival compared to wild-type patients treated with radical surgery.
In addition, FGFR3 mutations were more frequent in low-grade UTUCs with early-stage disease (pT1, pT2,
and pT3).
Conclusion
Genomic characterization of UTUC is destined to become increasingly important, and
more efforts aimed at implementing UTUC genomics analysis are warranted.
Keywords
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Article Info
Publication History
Published online: June 17, 2022
Accepted:
June 13,
2022
Received in revised form:
June 12,
2022
Received:
April 28,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
