Abstract
Background
A novel prognostic model was recommended for patients with metastatic RCC (mRCC) by
the International mRCC Database Consortium (IMDC). In this study, we aimed to externally
validate a novel risk model for the IMDC-favorable risk group in patients with mRCC.
Methods
The Turkish Oncology Group Kidney Cancer Consortium (TKCC) is a multicenter registry
that includes 13 cancer centers in Turkey. As described by Schmidt et al., 3 parameters
(ie, time from diagnosis to systemic therapy <3 vs. ≥3 years, Karnofsky Performance
Status [KPS] 80 vs. >80, and the presence of brain, liver, or bone metastasis) were
used to divide the IMDC favorable risk group into 2 new categories: very favorable
and favorable risk groups. The primary endpoint was overall survival (OS). Time to
treatment failure (TTF) and objective response rate (ORR) in the very favorable and
favorable risk groups were the secondary endpoints.
Results
A total of 545 patients with mRCC from all IMDC risk groups and 112 patients from
the favorable risk group were included in this study. According to the novel classification
model, 44 (39.3%) and 68 (60.7%) patients with former favorable risk were categorized
into very favorable and favorable risk groups, respectively. The median OS (55.8 months
vs. 34.2 months, P = .025) and TTF (25.5 months vs. 15.5 months, P = .010) were longer in the very favorable risk group than in the favorable risk group.
The concordance index of the new IMDC model in all patients was 0.65 for OS. Despite
the higher ORR in the very favorable risk group than in the favorable risk group,
the difference between the groups was not statistically significant (52.4% vs. 44.7,
P = .573).
Conclusions
This was the first study to externally validate the novel IMDC risk model presented
in the American Society of Clinical Oncology Genitourinary Cancers Symposium 2021.
Keywords
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Article info
Publication history
Published online: July 14, 2022
Accepted:
July 9,
2022
Received in revised form:
June 30,
2022
Received:
April 18,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
