Abstract
Antibody-drug conjugates (ADCs) reflect a new promising approach in prostate cancer,
even more so after the practice-changing results in other malignancies, either hematologic
or solid. ADCs consist of monoclonal antibodies (mAb) targeted at specific antigens
overly expressed on cancer cells compared to normal cells. A cytotoxic payload is
attached to the mAb using a stable linker. In prostate cancer, PSMA, STEAP1, TROP2,
CD46 and B7-H3 are antigens currently being studied as targets for ADCs. In this paper,
we discuss the composition of ADCs and focus on their application and challenges as
treatment options in prostate cancer.
Keywords
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Article info
Publication history
Published online: July 23, 2022
Accepted:
July 19,
2022
Received in revised form:
July 18,
2022
Received:
July 5,
2022
Identification
Copyright
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