Abstract
Objectives
To clarify the impact of body mass index (BMI) on treatment outcomes including survival,
tumor response, and adverse events (AEs) in patients with advanced renal cell carcinoma
(RCC) or urothelial carcinoma (UC) treated with immune checkpoint inhibitors (ICIs)
in an Asian population.
Methods
We retrospectively evaluated 309 patients with advanced RCC or UC who received ICIs
between September 2016 and July 2021. The patients were divided into high- (i.e.,
≥25 kg/m2) and low-BMI (<25 kg/m2) groups according to the BMI at the time of treatment initiation.
Results
Overall, 57 patients (18.4%) were classified into the high-BMI group. In RCC patients
treated with ICIs as first-line therapy or UC treated with pembrolizumab, progression-free
survival (PFS) (p = 0.309; p = 0.842), overall survival (OS) (p = 0.701; p = 0.983), and objective response rate (ORR) (p = 0.163; p = 0.553) were comparable between the high- and low-BMI groups. In RCC patients treated
with nivolumab monotherapy as later-line therapy, OS (p = 0.101) and ORR (p = 0.102) were comparable, but PFS was significantly longer in the high-BMI group
(p = 0.0272). Further, multivariate analysis showed that BMI was not an independent
factor of PFS or OS in all the treatment groups (any, p>0.05). As for AE profiles, in nivolumab monotherapy, the rate was significantly higher
in the high-BMI group (p = 0.0203), whereas in the other two treatments, the rate was comparable.
Conclusions
BMI was not associated with survival or response rates of advanced RCC or UC patients
treated with ICIs in an Asian population. AEs might frequently develop in high-BMI
patients with RCC in nivolumab monotherapy.
Keywords
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Article info
Publication history
Published online: August 05, 2022
Accepted:
August 3,
2022
Received in revised form:
July 26,
2022
Received:
February 17,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
