Abstract
The main modality of management of paratesticular mesothelioma remains orchiectomy
while the use of adjuvant chemotherapy has not yet been explored. We aim to analyse
the outcome of the multimodal management protocol in testicular mesothelioma We conducted
a retrospective analysis of patients registered and treated for testicular mesothelioma
between 2009 and 2019 in an oncology tertiary care hospital. Patients presenting with
nodal, metastatic disease were treated with adjuvant, palliative chemotherapy respectively
and their response to treatment was periodically monitored. Eight patients (3 early,
1 nodal, 4 metastatic) with median age of 58 years was included in the study. Patients
who had limited (early, nodal) disease (n = 4) had overall survival ranging from 20
to 140 months while metastatic disease (n = 4) had poor outcomes with overall survival
ranging from 2 to 13 months. Surgery remains to be an important modality of therapy
that improves the local control and overall outcomes and the quality of life even
in patients with metastatic disease at the time of diagnosis. Adjuvant chemotherapy
might play a role in effective management of locoregional disease. The performance
status, the extent of disease at the time of presentation are the important prognostic
factors in deciding the outcome of the disease management.
Keywords
Abbreviations:
PET (Positron emission tomography), CECT (Contrast-enhanced computed tomography), AFP (Alpha-fetoprotein), HCG (Human chorionic gonadotropin), LDH (Lactate dehydrogenase)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: September 10, 2022
Accepted:
September 2,
2022
Received in revised form:
August 30,
2022
Received:
June 7,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
